Fig. 1. Melanoma cells (10⁵) were plated in tissue culture dishes (60 mm), and d--tocopheryl succinate (-TS) and sodium succinate plus ethanol were added to separate cultures 24 hours after plating. Drugs and medium were changed at 2 and 3 days after treatment. Photomicrographs were taken 4 days after treatment. Control cultures showed fibroblastic cells as well as round cells in clumps; a) cultures treated with ethanol (1%) and sodium succinate (5–6 µg/ml) also exhibited fibroblastic morphology with fewer round cells; b) -TS treated cultures c) 5 µg/mL, and d) 6 mg/mL, showed a dramatic change in morphology [20] x300.