Fig. 2. Proposed mechanisms for the actions of CLA on PGE₂ production (from AA) and bone metabolism. Block arrows indicate biochemical reaction processes where CLA and linoleic acid participate. Line arrows indicate possible effects of CLA and its metabolites on PGE₂ metabolism and their subsequent action on bone [34]. Phospholipase A₂=PLA₂. Lipoxygenase enzyme=LO.