Fig. 1. Estimated changes (% with 95% confidence intervals) in risk of coronary heart disease (CHD) associated with isocaloric dietary substitutions. Adjusted for coronary risk factors and total energy intake. Sat=saturated fat, Carbo=carbohydrate, Mono=monounsaturated fat, Poly=polyunsaturated fat, Trans=trans fatty acids, Sat-Carbo=substitute carbohydrates for saturated fat. (Reproduced from [14] with permission of the Massachusetts Medical Society, Copyright © 1997 Massachusetts Medical Society.)