Fig. 3. Intracellular vitamin C concentrations (mean ± SD) in circulating cells as a function of dose in women. Cells were isolated when steady-state was achieved for each dose. For neutrophils, samples were available from 13 women at doses 0–200 mg daily; from 11 women at doses of 400 and 100 mg daily, and from 10 women at 2500 mg daily. For lymphocytes, monocytes and platelets, samples were available from 13 women at 30 mg daily; from 12 women at 60 mg daily; from six women at 100 mg daily; from two women at 400 and 1000 mg daily; from nine women at 2500 mg daily. Reproduced with permission from Proceedings of The National Academy of Sciences, from which details of the study can be obtained [51].