Fig. 3. Simplified schematic of eicosanoid biosynthesis from food sources of omega-6 and omega-3 fatty acids or their derived metabolic intermediate progenitors GLA, DGLA, AA, and EPA (GLA = gamma linolenic acid, DGLA = dihomo-gamma linolenic acid, AA = arachidonic acid, EPA = eicosapentaenoic acid; COX = cyclooxygenase, LIPOX = lipoxegenase; PG = prostaglandin, PGI = prostacyclin, TX = thromboxane, LT = leukotriene, OH-DGLA = 15-hydroxydihomo-gamma linolenic acid; 5, 6 = delta 5 and 6 desaturase enzymes). Subscripts denote the total number of double bonds in each molecules structure and the series to which it belongs.