Journal of the American College of Nutrition, Vol 1, Issue 1 41-48, Copyright © 1982 by American College of Nutrition
Cradle-to-grave atherosclerosis: high density lipoprotein cholesterol
C. J. Glueck
This presentation reviews environmental and genetic factors that relate to
high density lipoprotein cholesterol, the most potent independent
lipoprotein risk factor for coronary heart disease. Although at least three
decades of work have focused upon the primary atherogenic lipoprotein, low
density lipoprotein cholesterol (C-LDL), which has a strong positive
association with coronary heart disease (CHD), it has only been in the past
decade that detailed epidemiologic and biochemical studies have revealed
that high density lipoprotein cholesterol (C-HDL) is the most potent
lipoprotein cholesterol related to coronary heart disease; this
relationship is, however, inverse.