JACN Did you know that you can get alerts when a new issue is online?
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Loughead, J. L.
Right arrow Articles by Khoury, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Loughead, J. L.
Right arrow Articles by Khoury, J. C.

Journal of the American College of Nutrition, Vol 10, Issue 2 123-126, Copyright © 1991 by American College of Nutrition

JOURNAL ARTICLE

A role for magnesium in neonatal parathyroid gland function?

J. L. Loughead, F. Mimouni, R. C. Tsang and J. C. Khoury
Department of Pediatrics, University of Cincinnati College of Medicine, Ohio.

Little is known of the factors regulating parathyroid function in the neonatal period. Twenty-seven term infants born after uncomplicated pregnancies, labors, and deliveries were studied to test the hypothesis that in normal newborns the amplitude of parathyroid hormone (PTH) response to decreasing serum ionized calcium (iCa) correlates with serum magnesium (Mg) concentrations. Serum iCa (ion selective electrode, Radiometer ICA 1), PTH (1-84 intact molecules, radioimmunoassay) and Mg (atomic absorption) were measured at birth (cord blood) and 24 hours of age. Repeated measures analysis of covariance showed decreasing serum iCa (p less than 0.01) and increasing serum Mg (p less than 0.01) and PTH (p less than 0.01) over time. The change in PTH over the first 24 hours was directly correlated with cord blood (r = 0.38, p less than 0.05) and 24-hr Mg concentrations (r = 0.53, p less than 0.01). We conclude that the ability of the parathyroid gland to respond to decreasing serum iCa after birth is directly related to Mg status. We speculate that neonatal hypomagnesemia may lead to a blunted PTH secretory response, thus contributing to early neonatal hypocalcemia.


This article has been cited by other articles:


Home page
 Endocr. Rev.Home page
C. S. Kovacs and H. M. Kronenberg
Maternal-Fetal Calcium and Bone Metabolism During Pregnancy, Puerperium, and Lactation
Endocr. Rev., December 1, 1997; 18(6): 832 - 872.
[Abstract] [Full Text]

Home page
 Reproductive SciencesHome page
M. Bardicef, O. Bardicef, Y. Sorokin, B. M. Altura, B. T. Altura, and L. M. Resnick
Perinatal Cellular Ion Metabolism: 31P-Nuclear Magnetic Resonance Spectroscopic Analysis of Intracellular Free Magnesium and pH in Maternal and Cord Blood Erythrocytes
Reproductive Sciences, March 1, 1996; 3(2): 66 - 70.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1991 by the American College of Nutrition.