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Journal of the American College of Nutrition, Vol 11, Issue 3 330-333, Copyright © 1992 by American College of Nutrition

JOURNAL ARTICLE

Cardiomyopathy of copper deficiency: effect of vitamin E supplementation

M. Fields, C. G. Lewis and M. D. Lure
Carbohydrate Nutrition Laboratory, Beltsville Human Nutrition Research Center, MD 20705.

The present study was undertaken to determine whether the intraperitoneal injection of vitamin E to copper-(Cu) deficient rats fed fructose will protect the animals against the severity of Cu deficiency. Cu-deficient and adequate rats were fed a diet containing 62% carbohydrate as fructose. Half the Cu-deficient rats fed fructose were injected daily with vitamin E. Vitamin E treated rats were not protected against the lethal consequences of the interaction between Cu and fructose. These data provide evidence that the cardiomyopathy of Cu deficiency in rats consuming a fructose-based diet cannot be ameliorated by vitamin E supplementation.




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Copyright © 1992 by the American College of Nutrition.