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Journal of the American College of Nutrition, Vol 11, Issue 3 330-333, Copyright © 1992 by American College of Nutrition
JOURNAL ARTICLE |
M. Fields, C. G. Lewis and M. D. Lure
Carbohydrate Nutrition Laboratory, Beltsville Human Nutrition Research Center, MD 20705.
The present study was undertaken to determine whether the intraperitoneal injection of vitamin E to copper-(Cu) deficient rats fed fructose will protect the animals against the severity of Cu deficiency. Cu-deficient and adequate rats were fed a diet containing 62% carbohydrate as fructose. Half the Cu-deficient rats fed fructose were injected daily with vitamin E. Vitamin E treated rats were not protected against the lethal consequences of the interaction between Cu and fructose. These data provide evidence that the cardiomyopathy of Cu deficiency in rats consuming a fructose-based diet cannot be ameliorated by vitamin E supplementation.
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