Journal of the American College of Nutrition, Vol 11, Issue 5 512-518, Copyright © 1992 by American College of Nutrition

JOURNAL ARTICLE

Role of nutrition in the management of malnutrition and immune dysfunction of trauma

F. B. Cerra
Dept. of Clinical Nutrition, University of Minnesota, Minneapolis.

Current nutrition support improves patient outcome in trauma patients. It appears to do so by limiting the adverse effects of specific nutrient or generalized nutrient deficiencies. Immunosuppression, however, continues as a significant clinical problem. This immunosuppression appears to be part of the inflammatory response that accompanies trauma, and in part, to represent the need for conditional nutrients in this setting. Three nutrients that are being evaluated include arginine, uracil as ribonucleic acid and omega-3 polyunsaturated fatty acids. Animal studies report improved immune function. Early clinical trials are reporting improved immune function and patient outcomes.

This article has been cited by other articles:

				L. Schlegel, C. Coudray-Lucas, F. Barbut, J. Le Boucher, A. Jardel, S. Zarrabian, and L. Cynober Bacterial Dissemination and Metabolic Changes in Rats Induced by Endotoxemia following Intestinal E. coli Overgrowth Are Reduced by Ornithine {{alpha}}-Ketoglutarate Administration J. Nutr., December 1, 2000; 130(12): 2897 - 2902. [Abstract] [Full Text] [PDF]