Journal of the American College of Nutrition, Vol 12, Issue 1 61-65, Copyright © 1993 by American College of Nutrition

JOURNAL ARTICLE

Zinc kinetics in patients with bone demineralization due to physical immobilization

A. Higashi, T. Nakamura, S. Nishiyama, M. Matsukura, S. Tomoeda, Y. Futagoishi, M. Shinohara and I. Matsuda
Department of Pediatrics, Kumamoto University Medical School, Japan.

To examine the relationship between zinc (Zn) status and bone demineralization, a body Zn kinetics study was performed with 74 (37 male, 37 female) disabled persons ranging in age from 16 to 45 years. Three groups were classified according to degree of limited mobility: group 1 (n = 23), capable of walking; group 2 (n = 20), capable of crawling; group 3 (n = 31), bed-ridden, Serum Zn levels were similar in the three groups, whereas body Zn clearance and the distribution of Zn showed a pattern [group 1 < group 2 < group 3 (p < 0.01, p < 0.05)], with the reverse in cases of bone mineral density (BMD) [group 1 > group 2 > group 3 (p < 0.01)]. Renal handling of Zn did not different among the three groups. There was a negative correlation between Zn distribution volume and values of BMD (p < 0.005, gamma = 0.387). Thus, various organs, as well as the skeleton, are Zn deficient in immobilized patients.

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