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Journal of the American College of Nutrition, Vol 14, Issue 1 24-28, Copyright © 1995 by American College of Nutrition

JOURNAL ARTICLE

Excessive urinary oxalate excretion occurs in long-term TPN patients both with and without ileostomies

A. L. Buchman, A. A. Moukarzel and M. E. Ament
Section of Gastroenterology, Baylor College of Medicine, Houston, TX, USA.

OBJECTIVE: To determine if excessive oxalate and deficient citrate excretion were associated with TPN-associated nephropathy. DESIGN: Crossectional cohort. SETTING: Outpatient clinic. SUBJECTS: Twenty-five patients (15 males, 10 females) aged 51 +/- 17 (mean +/- SD) years who had received home total parenteral nutrition (TPN) for 10 +/- 4 years. Fifteen subjects had ileostomies (Group A) and 10 had functional colons (Group B). OUTCOME MEASURES: Glomerular filtration rate (GFR), tubular reabsorption of phosphate (TRP), urinary oxalate and citrate excretion. RESULTS: The mean GFR was 68.1 +/- 34.5 ml/minute/1.73 m2 and did not differ between Groups A and B. The mean TRP was 65.0 +/- 32.2% for Group A and 80.5 +/- 16.0% for Group B. The difference was not statistically significant. Urinary oxalate and citrate excretion were 40.2 +/- 30.2 and 324.4 +/- 239.0 mg/day respectively for Group A, and 63.2 +/- 34.2 and 474.8 +/- 936.3 respectively for Group B. The differences were not statistically significant. Thirty-eight percent (38%) of patients with ileostomies and 78% of patients without ileostomies had excessive urinary oxalate excretion (> 40 mg/day). Fifteen percent (15%) of patients with ileostomies and 50% of patients without ileostomies had decreased urinary citrate excretion (< 140 mg/day). CONCLUSIONS: Increased endogenous oxalate production may occur in patients receiving long-term TPN.


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 JPEN J Parenter Enteral NutrHome page
L. P. de la Vega, J. C. Lieske, D. Milliner, J. Gonyea, and D. G. Kelly
Urinary Oxalate Excretion Increases in Home Parenteral Nutrition Patients on a Higher Intravenous Ascorbic Acid Dose
JPEN J Parenter Enteral Nutr, November 1, 2004; 28(6): 435 - 438.
[Abstract] [Full Text] [PDF]


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