HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fields, M. Articles by Lewis, C. G. Search for Related Content PubMed PubMed Citation Articles by Fields, M. Articles by Lewis, C. G.

Dietary Fructose but Not Starch is Responsible for Hyperlipidemia Associated with Copper Deficiency in Rats: Effect of High-Fat Diet

Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, ARS, United States Department of Agriculture, Beltsville, Maryland

Address reprint requests to: Meira Fields, PhD, FACN, USDA, ARS, BHNRC, NRFL; Bldg. 307, Rm. 330, BARC-East; Beltsville, MD 20705-2350

Objective: To test the hypothesis that copper deficiency in rats may be hyperlipidemic only when the diets consumed contain nutrients which contribute to blood lipids such as fructose and high fat.

Methods: Weanling male Sprague Dawley rats were fed diets which contained either starch or fructose as their sole carbohydrate source. The diets were either inadequate (0.6 µg Cu/g) or adequate (6.0 µg Cu/g) in copper and contained either high (300 g/kg) or low (60 g/kg) fat. At the end of the 4th week the rats were killed. Livers were analyzed for copper content. Plasma was analyzed for cholesterol and triglyceride concentrations.

Results: High-fat diet did not increase blood lipids in rats fed a copper-deficient diet containing starch. In contrast, the combination of high-fat diet with fructose increased blood triglycerides and fructose with copper deficiency resulted in a significant increases in blood cholesterol.

Conclusions: Hyperlipidemia of copper deficiency in rats is dependent on synergistic effects between dietary fructose and copper deficiency and fructose and amount of dietary fat. Hyperlipidemia does not develop if starch is the main source of dietary carbohydrate in a copper-deficient diet even if a high-fat diet is fed.

Key words: copper deficiency, starch, fructose, high-fat, cholesterol, triglycerides

This article has been cited by other articles:

				S. Weksler-Zangen, I. Raz, S. Lenzen, A. Jorns, S. Ehrenfeld, G. Amir, A. Oprescu, Y. Yagil, C. Yagil, D. H. Zangen, et al. Impaired Glucose-Stimulated Insulin Secretion Is Coupled With Exocrine Pancreatic Lesions in the Cohen Diabetic Rat Diabetes, February 1, 2008; 57(2): 279 - 287. [Abstract] [Full Text] [PDF]

				S. S Elliott, N. L Keim, J. S Stern, K. Teff, and P. J Havel Fructose, weight gain, and the insulin resistance syndrome Am. J. Clinical Nutrition, November 1, 2002; 76(5): 911 - 922. [Abstract] [Full Text] [PDF]