JACN Did you know that you can get alerts when a new issue is online?
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Malinow, M. R.
Right arrow Articles by Graf, E. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Malinow, M. R.
Right arrow Articles by Graf, E. E.
Journal of the American College of Nutrition, Vol. 19, No. 4, 452-457 (2000)
Published by the American College of Nutrition

Original Research

Increased Plasma Homocyst(e)ine after Withdrawal of Ready-to-Eat Breakfast Cereal from the Diet: Prevention by Breakfast Cereal Providing 200 µg Folic Acid

M. Rene Malinow, MD,, P. Barton Duell, MD, Andrea Irvin-Jones, BS, Barbara M. Upson, BS and Eric E. Graf, BS

Department of Pathobiology, Oregon Regional Primate Research Center, Beaverton (M.R.M., B.M.U., E.E.G.), Portland, Oregon
Department of Medicine, Oregon Health Sciences University (M.R.M., P.B.D.), Portland, Oregon
Providence St. Vincent Hospital (A.I.-J.), Portland, Oregon

Address reprint requests to: M.R. Malinow, MD, Oregon Regional Primate Research Ctr, 505 NW 185th Ave, Beaverton, OR 97006-3448. E-mail: malinowr{at}ohsu.edu.

Objective: We tested the hypothesis that cessation of habitual ingestion of breakfast cereals would be associated with elevated plasma homocyst(e)ine concentrations. We anticipated that those subjects who reported consuming breakfast cereals containing 100 to 400 µg of folic acid per serving before entering the study would achieve higher plasma homocyst(e)ine concentrations if, in addition to their regular diet, they began ingesting a daily serving of breakfast cereal that contained less than 10 µg of folic acid per serving.

Design: Seventy-nine subjects consumed a daily serving of breakfast cereal containing either <10 µg or folic acid per serving (placebo) or breakfast cereal containing 200 µg of folic acid per serving (folic acid fortified).

Results: Cessation of intake of commercially available breakfast cereal was associated with homocyst(e)ine elevation. Breakfast cereal containing 200 µg folic acid per day was sufficient to maintain the homocyst(e)ine lowering effects of commercial cereals.

Conclusions: Habitual consumption of commercially available fortified breakfast cereals, usually containing 100 to 400 µg folic acid per serving, had significant homocyst(e)ine-lowering effects as shown by the homocyst(e)ine increase after cessation of habitual intake of commercial breakfast cereal. Substitution of breakfast cereal containing only 200 µg folic acid per day was sufficient to maintain the homocyst(e)ine-lowering effects of commercial cereals.

Key words: homocysteine, folic acid, breakfast cereal, atherosclerosis




This article has been cited by other articles:


Home page
 J. Am. Coll. Nutr.Home page
W. O. Song, C.-E. Chung, O. K. Chun, and S. Cho
Serum Homocysteine Concentration of US Adults Associated with Fortified Cereal Consumption
J. Am. Coll. Nutr., December 1, 2005; 24(6): 503 - 509.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
V. Ganji and M. R Kafai
Frequent consumption of milk, yogurt, cold breakfast cereals, peppers, and cruciferous vegetables and intakes of dietary folate and riboflavin but not vitamins B-12 and B-6 are inversely associated with serum total homocysteine concentrations in the US population
Am. J. Clinical Nutrition, December 1, 2004; 80(6): 1500 - 1507.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the American College of Nutrition.