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Journal of the American College of Nutrition, Vol 2, Issue 2 115-122, Copyright © 1983 by American College of Nutrition

CLINICAL TRIAL

The effect of alpha-tocopherol on premenstrual symptomatology: a double-blind study

R. S. London, G. S. Sundaram, L. Murphy and P. J. Goldstein

In a double-blind, randomized dose-response study, 75 women with benign breast disease were administered a written questionnaire in which they scored the severity of premenstrual syndrome (PMS) symptoms before and after two months of treatment with placebo or alpha-tocopherol (150, 300, or 600 IU/day). Controlling for age and pretreatment scores, alpha-tocopherol had a significantly greater effect than placebo, improving three of the four classes of PMS symptoms. These findings suggest that vitamin E supplementation may be of value in women with severe PMS symptoms.




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Copyright © 1983 by the American College of Nutrition.