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Journal of the American College of Nutrition, Vol. 20, No. 1, 81-86 (2001)
Published by the American College of Nutrition

Original Research

The Influence of Nutrition on IGF-1 in Tube-Fed Profoundly Retarded Adults

Norris R. Glick, MD,,, Milton H. Fischer, PhD and William N. Adkins, Jr, MD,

Central Wisconsin Center (N.R.G., M.H.F., W.N.A.), University of Wisconsin-Madison, Madison, Wisconsin
Department of Pediatrics (N.R.G., W.N.A.), University of Wisconsin-Madison, Madison, Wisconsin
Department of Rehabilitation Medicine (N.R.G.), University of Wisconsin-Madison, Madison, Wisconsin

Address correspondence to: Norris R. Glick, M.D., Central Wisconsin Center, 317 Knutson Drive, Madison, WI 53704. E-mail: nrglick{at}facstaff.wisc.edu

Objective: This study was conducted to determine whether IGF-1 concentrations are low in nonambulant profoundly retarded adults and to identify associated nutritional factors.

Methods: Serum IGF-1, albumin, pre-albumin, creatinine, zinc (Zn) and plasma amino acids were measured before and after a four-week 25% increase in formula in 25 individuals, divided into those fed by day (Group A) or by night (Group B).

Results: Circulating IGF-1 was low in nine of the 22 subjects (40.9%) included in the analysis. Mean IGF-1 increased 10.4% (p=0.004). Despite high intakes of essential amino acids and Zn, initial mean plasma tryptophan and phenylalanine were low, and serum Zn was low in 40.9% of subjects. Plasma tryptophan was low at both samplings and correlated with circulating IGF-1 concentrations (p=0.02) at the beginning of the study. Serum IGF-1 and Zn also correlated (p=0.02) initially.

Conclusions: IGF-1 is commonly low in this population and is associated with low plasma amino acid and Zn concentrations, despite high intakes of these nutrients. The causes and clinical implications of these abnormalities need further study.

Key words: insulin-like growth factor-I, plasma amino acids, profoundly retarded, tryptophan, zinc






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