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Journal of the American College of Nutrition, Vol. 21, No. 4, 333-338 (2002)
Published by the American College of Nutrition

No Antioxidant Effect of Combined HRT on LDL Oxidizability and Oxidative Stress Biomarkers in Treated Post-Menopausal Women

Isabelle Bureau, PhD, François Laporte, PhD, Max Favier, MD, Henri Faure, PhD, Meira Fields, PhD, FACN, Alain E. Favier, PhD, FACN and Anne-Marie Roussel, PhD, FACN

LBSO, University J. Fourier, Domaine de la Merci, La Tronche (I.B.,F.L., H.F., A.E.F., A.-M.R.), FRANCE
Department of Gynecology, Grenoble Hospital, Grenoble (M.F.), FRANCE
Human Nutrition Research Center, USDA, Beltsville, Maryland (M.F.)

Address reprint requests to: Pr. A.M. Roussel, LBSO/UFR de Pharmacie, 38700 La Tronche, France E-mail: Anne-Marie.Roussel{at}ujf-grenoble.fr

Objective: To compare oxidative stress and LDL oxidizability in postmenopausal women with and without HRT.

Methods: In a cross sectional study, two groups of women, with or without combined per os HRT (1.5–2 mg estrogen associated with 10 mg dydrogesteron), were age and duration of menopause matched. Women were recruited after medical examination at LBSO (Oxidative Stress Laboratory), Joseph Fourier University, Grenoble, and Department of Gynecology, Grenoble University Hospital, France. Main outcome measures included determination of lipid profile and oxidative stress biomarkers (TBARS, LDL oxidizability, auto-antibodies against oxidized-LDL). Measurement of circulating levels of vitamin C, E, ß-carotene, lycopene and total antioxidant plasma capacity.

Results: HRT led to decreased plasma total and LDL cholesterol (p < 0.05), but did not affect oxidizability and oxidation of LDL. Circulating levels of antioxidant vitamins (ß-carotene, vitamin C, vitamin E/triglycerides) and total antioxidant capacity of plasma and lipid peroxidation, assessed by plasma TBARs, were not different from controls in postmenopausal women receiving HRT.

Conclusion: This study suggests that even if combined HRT modifies the blood lipid profile, it does not appear to influence oxidative status.

Key words: Combined HRT, LDL oxidizability, oxidative stress biomarkers

Abbreviations: LDL = Low Density Lipoprotein • HDL = High Density Lipoprotein • HPLC = High Performance Liquid Chromatogratography • TAS = Total Antioxidant Plasma Capacity • HRT = Hormonal Replacement Therapy




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