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Original Research |
Department of Nutrition (W.K.A.-D., E.B.R., W.C.W., M.J.S., F.B.H.), Department of Epidemiology (E.B.R., W.C.W., M.J.S.), Harvard School of Public Health, Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women’s Hospital (E.B.R., W.C.W., M.J.S., F.B.H.), Boston, Massachusetts
Address correspondence to: Wael K Al-Delaimy, MD, PhD, Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115. E-mail: wael{at}hsph.harvard.edu
Objective: Our aim in this study was to assess the relationship between magnesium intake and risk of coronary heart disease (CHD) among men.
Methods: A total of 39,633 men in the Health Professionals Follow-up Study who returned a dietary questionnaire in 1986 were followed up for 12 years. Intakes of magnesium, zinc and potassium and other nutrients were assessed in 1986, 1990 and 1994. Total CHD incidence (nonfatal myocardial infarction (MI) and fatal CHD) was ascertained by biennial questionnaire and mortality surveillance confirmed by medical record review. Standard CHD risk factors were recorded biennially.
Results: During 12 years of follow-up (414,285 person-years), we documented 1,449 cases of total CHD (1,021 non-fatal MI cases, and 428 fatal CHD). The age-adjusted relative risk (RR) of developing CHD in the highest quintile (median intake = 457 mg/day) compared with the lowest quintile (median intake = 269 mg/day) was 0.73 (95% CI 0.62–0.87, p for trend <0.0001). After controlling for standard CHD risk factors and dietary factors, the RR for developing CHD among men in the highest total magnesium intake quintile compared with those in the lowest was 0.82 (95% CI 0.65–1.05, p for trend = 0.08). For supplemental magnesium intake, the RR comparing the highest quintile to non-supplement users was 0.77 (95% CI 0.56–1.06, p for trend = 0.14).
Conclusions: These results suggest that intake of magnesium may have a modest inverse association with risk of CHD among men.
Key words: magnesium, coronary heart disease, diet, supplements, cohort
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