JACN Did you know that you can get alerts when a new issue is online?
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Takeda, R.
Right arrow Articles by Kimura, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takeda, R.
Right arrow Articles by Kimura, M.
Journal of the American College of Nutrition, Vol. 23, No. 6, 712S-714S (2004)
Published by the American College of Nutrition

A Study on Spontaneously Obese Rat (Minko Rat) with Abnormal Lipid Metabolism, Strength and Mineral Concentrations in Bone

Ryuji Takeda, MD, Takashi Nakamura, MD, PhD, Masayo Imanishi, Madoka Ishida, Fumiko Yano, Takahisa Takeda, MD, PhD and Mieko Kimura, PhD

Graduate School of Medicine, Kyoto University (R.T., T.N.), JAPAN
Takeda Research Institute of Life Science (R.T., M.I., M.I., T.T., M.K.), JAPAN
Kyoto School of Biology-Oriented Science and Technology, Kinki University, Wakayama (F.Y.), JAPAN

Address reprint requests to: Ryuji Takeda, MD, Takeda Research Institute of Life Science, Kyoto Research Park, 134 Tyudoji Minamimachi Shimogyoku Kyoto 600-8813, JAPAN. E-mail: tls{at}takedahp.or.jp

Objectives: In view of the prevalence of osteoporosis in Japan, which surveys have shown has almost doubled over the last ten years, contributory factors, additional to the mineral status, that affect bone stiffness have been explored in spontaneously obese (Minko) rats.

Methods: Bone stiffness and strength as well as content of Mg, Ca, P, Na, K, and trace minerals in femurs were compared in male and female Minko rats, which have abnormal lipid metabolism.

Results: Mechanical study of femurs indicated that bone stiffness of male rats was significantly higher than that of female rats, but that Mg, Ca, P, Na, Zn, Sr and Fe concentrations in male rats were significantly lower than that of female rats, while S and K concentrations in male rats were significantly higher than that of female rats.

Conclusions: These results suggest that bone strength isn’t determined only by mineral concentrations such as Mg, Ca and P. We reported that the bone strength of "Minko Rats" was significantly higher than bone strength of control rats, but there was no significant difference of Ca and P concentrations between the two groups of rats.

Key words: bone strength, Ca, Mg P, lipid metabolism, obese rat






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the American College of Nutrition.