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Journal of the American College of Nutrition, Vol. 24, No. 1, 22-29 (2005)
Published by the American College of Nutrition

Dietary Carbohydrates and Glycated Proteins in the Blood in Non Diabetic Subjects

Giovanni Misciagna, MD, PhD, Giampietro De Michele, PhD, Anna M. Cisternino, PhD, Vito Guerra, PhD, Giancarlo Logroscino, MD, PhD and Jo L. Freudenheim, PhD

Laboratory of Epidemiology (G.M., A.M.C., V.G.), IRCCS "S. De Bellis," Research Hospital for Digestive Diseases, Castellana, Bari, ITALY
Laboratory of Clinical Pathology (G.D.M.), IRCCS "S. De Bellis," Research Hospital for Digestive Diseases, Castellana, Bari, ITALY
Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston (G.L.)
Department of Social and Preventive Medicine, School of Public Health and Allied Health Professions, University at Buffalo, Buffalo (J.L.F.)

Address reprint requests to: Giovanni Misciagna, MD, PhD, Laboratorio di Epidemiologia, IRCCS "S. De Bellis," Ospedale Gastroenterologico, Castellana, (Bari), 70013, ITALY. E-mail: gmisciag{at}libero.it

Objectives: To evaluate in non diabetic subjects the association of dietary carbohydrates with fructosamine, a measure of total non enzymatic glycated proteins in the blood associated with mortality, particularly from cardiovascular diseases.

Methods: A population sample of 252 subjects (137 men and 115 women, mean age 57) without diabetes and with fasting serum glucose <126 mg/100 mL, participated in the study. Diet and dietary glycemic load were measured with a validated food frequency questionnaire. Fructosamine was measured with a standard colorimetric method. Multiple linear regression was used to analyze the data.

Results: Serum fructosamine was positively associated with dietary glycemic load. Moreover, it was positively associated with intake of polyunsaturated fats and alcohol; and negatively with intake of monounsaturated fats, and with physical activity.

Conclusion: The quality of carbohydrate and fat, as well as physical activity, may explain the variation of non enzymatic glycated serum proteins in non diabetic subjects.

Key words: fructosamine, dietary carbohydrates, dietary fats, glycemic load, non diabetic subjects






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