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Influence of Short-Chain Fructo-Oligosaccharides (sc-FOS) on Absorption of Cu, Zn, and Se in Healthy Postmenopausal Women

Laboratoire Nutrition, Vieillissement et Maladies Cardiovasculaires, Université Joseph Fourier, Domaine de la Merci, 38700 La Tronche (V.D., J.A., A.M.R.)
Département de Biologie Intégrée, Centre Hospitalier Universitaire, BP 217, 38043 Grenoble cedex 9 (V.D., J.A.)
Centre de Recherche en Nutrition Humaine d’Auvergne, Unité Maladies Métaboliques et Micronutriments, Centre de Recherche INRA Clermont-Ferrand/Theix, 63122 Saint Genès Champanelle (M.T., C.C., Y.R.)
Nutrihealth SA, 3 Avenue Paul Doumer, Rueil Malmaison, Paris (F.Bo)
Laboratoire de Nutrition Humaine, 58 rue Montalembert, 63009 Clermont-Ferrand (C.B.-D.), FRANCE
Cerestar R&D Center, Vilvoorde, Belgium, Nutrition & Toxicology Research Institute, Department of Human Biology, Maastricht University, Maastricht (F.Br), THE NETHERLANDS

Address reprint requests to: Véronique Ducros, PhD, Département de Biologie Intégrée, Centre Hospitalier Universitaire, BP 217, 38043 Grenoble cedex 9, France. E-mail: VDucros@chu-grenoble.fr

Objective: This study was carried out to evaluate the effect of short-chain fructooligosaccharides (sc-FOS) on the absorption of Cu, Zn, and Se among postmenopausal women who are potential candidates to subclinical trace element deficiencies.

Design: A randomized double blind cross-over study.

Setting: This study was carried out at the Human Nutrition Research Center, Clermont-Ferrand, France.

Subjects: 11 postmenopausal women aged 53–70 y, not taking hormone replacement therapy were enrolled and completed the study.

Interventions: Diets with 10 g/day sc-FOS or placebo were given for 5 weeks each in random order followed by a wash-out period of at least 3 weeks. At the end of each period, stable isotopes (3.19 mg ⁶⁷Zn as ZnCl₂, 2.06 mg ⁶⁵Cu as CuCl₂ and 52.3 µg ⁷⁴Se as sodium selenite) and radiopaque pellets (as fecal excretion index) were administered during lunch. Stools were collected for the next 5–7 days. Isotopes were determined by ICP-MS (Cu and Zn) or GC-MS (Se).

Results: Copper absorption was significantly enhanced (p = 0.042) by sc-FOS. No effect of sc-FOS was observed on Zn, and Se absorption.

Conclusion: To our knowledge, this is the first study on the influence of sc-FOS on trace element metabolism. The observed increase in copper absorption may be of interest regarding daily copper requirements in menopausal women. However, the relevance of this observation remains to be established.

Key words: fructo-oligosaccharides, absorption, trace elements, postmenopausal women, stable isotopes

Abbreviations: HRT = hormone replacement therapy • GC-MS = gas chromatography-mass spectrometry • ICPMS = inductively coupled plasma mass spectrometry • IR = isotopic ratio • NDOs = nondigestible oligosaccharides • sc-FOS = short-chain fructooligosaccharides

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