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Journal of the American College of Nutrition, Vol. 24, No. 2, 140S-145S (2005)
Published by the American College of Nutrition

Role of Protein and Amino Acids in the Pathophysiology and Treatment of Sarcopenia

Hans C. Dreyer, PhD, PT and Elena Volpi, MD, PhD

Departments of Rehabilitative Sciences (H.C.D.), Internal Medicine (E.V.), Sealy Center on Aging (H.C.D., E.V.), University of Texas Medical Branch, Galveston, Texas

Address reprint requests to: Elena Volpi, M.D., Ph.D., Division of Geriatrics and Sealy Center on Aging, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0460

Sarcopenia, the loss of skeletal muscle mass and function with aging, is a multifactorial condition that slowly develops over decades and becomes a significant contributor to disability in the older population. Malnutrition and alterations in the muscle anabolic response to nutritional stimuli have been identified as potentially preventable factors that may significantly contribute to sarcopenia. Thus, nutritional interventions may be useful for the prevention and treatment of sarcopenia.

Key words: aging, skeletal muscle, dietary protein, metabolism, anabolism




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