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Decreasing Oxidative Stress with Choline and Carnitine in Women

Department of Nutrition and Agricultural Experiment Station, University of Tennessee, Knoxville, Tennessee

Address reprint requests to: Dileep S. Sachan, DVM, PhD, Professor, Nutrition Department, 229 JHB, University of Tennessee, Knoxville, TN 37996-1920. E-mail: dsachan{at}utk.edu

Objective: Fatty acid oxidation is predominantly a mitochondrial event, which is enhanced by dietary choline and carnitine supplementation resulting in extra reactive oxygen species (ROS) load. The objective was to assess oxidative stress level by thiobarbituric acid reactive substances [TBARS] in choline and carnitine supplemented healthy women before and after mild exercise.

Methods: Nineteen free-living women completed the placebo control study in which choline and/or L-carnitine was orally taken for 21 days. Anthropometric measurements, dietary recall, exercise routine and blood samples were analyzed to determine body composition, nutrients intake, distance walked and biochemical markers related to oxidative stress.

Results: TBARS were significantly lower in the groups supplemented with choline, carnitine or both and the mild exercise (walking) was not a deterrent in this effect of the supplements. Serum vitamin A and E concentrations were higher in the supplemented groups even though the consumption of these nutrients was not different among the groups.

Conclusion: Choline and carnitine supplementation lowers lipid peroxidation, and promotes conservation of retinol and -tocopherol in free-living women.

Key words: antioxidant, oxidative stress, choline, carnitine, women

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