JACN Did you know that you can get alerts when a new issue is online?
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Canales, A.
Right arrow Articles by Sánchez-Muniz, F. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Canales, A.
Right arrow Articles by Sánchez-Muniz, F. J.
Journal of the American College of Nutrition, Vol. 26, No. 3, 225-232 (2007)
Published by the American College of Nutrition

Effect of Walnut-Enriched Restructured Meat in the Antioxidant Status of Overweight/Obese Senior Subjects with at Least One Extra CHD-Risk Factor

Amaia Canales, Juana Benedí, PhD, Meritxell Nus, PhD, Josana Librelotto, PhD, Jose M Sánchez-Montero, PhD and Francisco J. Sánchez-Muniz, PhD

Departamento de Nutrición y Bromatología I (Nutrición)
Departamento de Farmacología
Grupo de Biotransformaciones
Departamento de Química Orgánica y Farmaceútica, Facultad de Farmacia, Universidad Complutense, Madrid, SPAIN

Address correspondence to: Professor Dr. Francisco J. Sánchez-Muniz, Departamento de Nutrición y Bromatologia I (Nutrición), Facultad de Farmacia. Universidad Complutense, E-28040-Madrid, SPAIN. E-mail: frasan{at}farm.ucm.es

Background: A number of recent studies indicate that antioxidants reduce the oxidative stress associated with the development of coronary heart diseases (CHD).

Objective: (i) To investigate whether the erythrocyte catalase (CAT), superoxide dismutase (SOD), total glutathione, reduced glutathione (GSH), oxidized glutathione (GSSG), and lipid peroxidation (LPO), and serum uric acid and paraoxonase-1 (PON1) are modified at increased CHD-risk individuals consuming walnut-enriched meat (WM), (ii) to evaluate whether these changes were influenced by basal serum cholesterol, body mass index or smoking habit.

Design: The study was a non blinded, cross-over, placebo-controlled trial in which 22 volunteers (60% overweight and 40% obese) with increased CHD-risk were randomly assigned to receive WM or control meat (CM) during two different periods of 5 weeks.

Results: A significant interaction time*treatment (p < 0.05) was observed in all enzymes and substrates tested except HDL-C, uric acid and LPO. The treatment significantly increased CAT activity, total glutathione and GSSG (p < 0.05). Significant gender*time*treatment interaction (p = 0.043) for total glutathione was found increasing at the end of the WM period in male but not changing in female. Total glutathione and GSH/GSSG ratio (p < 0.05) were lower in smokers. Hypercholesterolemics presented higher uric acid (p < 0.05) but no enzyme activities or substrate concentrations were different from those of normocholesterolemics.

Conclusions: The WM tested appears to be a functional food as it improved the antioxidant status of increased CHD-risk volunteers. Despite its high energy content, it also appears adequate for overweight and obese people because did not exert negative effect upon body weight.

Key words: antioxidant status, functional food, lipid peroxidation, walnut-enriched meat

Abbreviations: BMI = Body mass index • CHD = Coronary heart disease • CAT = Catalase • Hb = Haemoglobin • CM = Control meat • LPO = Lipid peroxidation • MDA = Malondialdehyde • GSSG = Oxidized glutathione • ox-LDL = Oxidized-LDL • PON1 = Paraoxonase • PUFA = Polyunsaturated fatty acids • ROS = Reactive oxygen species • GSH = Reduced glutathione • SOD = Superoxide dismutase • WM = Walnut-enriched meat






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the American College of Nutrition.