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Journal of the American College of Nutrition, Vol. 26, No. 5, 462-470 (2007)
Published by the American College of Nutrition

Preliminary Findings: 25(OH)D Levels and PTH Are Indicators of Rapid Bone Accrual in Pubertal Children

Frances A. Tylavsky, DrPH, Kathryn M. Ryder, MD, Rongling Li, MD, PhD, Vicki Park, PhD, Catherine Womack, MD, John Norwood, MD, Laura D. Carbone, MD and Sulin Cheng, PhD

University of Tennessee Health Science Center (F.A.T., K.M.R., R.L., V.P., C.W., J.N., L.D.C.), Memphis, Tennessee
University of Jyväskylä (S.C.), Jyväskyla, FINLAND

Address reprint requests to: Frances A. Tylavsky, Dr.P.H., Department of Preventive Medicine, 66 N. Pauline St., Suite 633, Memphis, TN 38105. E-mail: ftylavsky{at}utmem.edu

Objective: The objective of this study was to evaluate the role of serum levels of 25(OH)D and PTH on the accumulation of whole body bone mass in a cohort of children.

Methods: This was a longitudinal study (1.98 ± 0.07 y) of sixty-nine children (89% Caucasian, 44% male) enrolled in a calcium supplementation trial. Bone area, bone mineral content (BMC) and density (BMD) of the whole body and radius were assessed using a QDR 2000 (Hologic, Inc) dual energy x-ray absorptiometer. Serum PTH and 25(OH)D were measured using radioimmunoassays.

Results: Vitamin D stores were inversely related gain in bone area (p < 0.002), BMC (p < 0.002) BMD (p < 0.027), as well as to PTH levels (p < 0.0001). Compared to those with adequate vitamin D stores (>34 ng/ml), those who had consistently low vitamin D stores (18 ng/ml) had a 8% larger gain in bone area (p < 0.05); 11% in BMC (p < 0.05) and no differences in gain in BMD; after adjusting for baseline bone measurements, race, gender, season measured, Tanner stage, and calcium intake.

Conclusions: High normal PTH with low-normal 25(OH)D stores and moderate to high calcium intake may be beneficial to accruing larger bone size and BMC during puberty.

Key words: dual energy x-ray absorptiometry, children, bone mass, vitamin D, parathyroid hormone






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Copyright © 2007 by the American College of Nutrition.