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Journal of the American College of Nutrition, Vol. 27, No. 2, 274-279 (2008)
Published by the American College of Nutrition

Body Size and Serum 25 Hydroxy Vitamin D Response to Oral Supplements in Healthy Older Adults

Miriam Blum, MD, Gerard E. Dallal, PhD and Bess Dawson-Hughes, MD

Bone Metabolism Laboratory (M.B., B.D.H.)
Biostatistics Department (G.E.D.), Jean Mayer U. S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts

Address correspondence to: Bess Dawson-Hughes, MD, Bone Metabolism Laboratory, Jean Mayer USDA, HNRC on Aging at Tufts University, 711 Washington Street, Boston, MA 02111. E-mail: bess.dawson-hughes{at}tufts.edu

Background: Vitamin D insufficiency is prevalent in the northeast United States. Since vitamin D insufficiency is readily amenable to supplementation, it is important to understand what factors are associated with serum 25 hydroxy vitamin D (25(OH)D) response to vitamin D supplementation.

Objective: In this study we examined the association of serum 25(OH)D response to vitamin D supplementation with body size in a population of elderly subjects.

Methods: 257 healthy, ambulatory men and women 65 years of age or older were randomly assigned to treatment with either 700 IU/day (17.5 µg/d) of supplemental vitamin D3 and 500 mg/day (12.5 mmol/d) of supplemental calcium, or to placebo.

Results: In multivariate regression analyses, after adjusting for baseline 25(OH)D, season, and sex, we found change in 25(OH)D to be inversely associated with baseline BMI (p = 0.01) in subjects treated with supplements for one year. Change in 25(OH)D was also negatively associated with other baseline anthropometric measurements in these subjects.

Conclusion: Our study implies that body size should be taken into account when estimating the amount of vitamin D intake needed to raise 25(OH)D to the desired level.

Key words: body size, body mass index, 25 hydroxy vitamin D, vitamin D3 supplements, elderly






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