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Journal of the American College of Nutrition, Vol. 27, No. 2, 332-336 (2008)
Published by the American College of Nutrition

Short-time Ingestion of Colas Influences the Activity Distribution at Bone Scintigraphy: Experimental Studies in the Mouse

Hans Jacobsson, MD, PhD

Departments of Radiology and Nuclear Medicine, Karolinska University Hospital, Stockholm, SWEDEN

Address correspondence to: Hans Jacobsson, Department of Radiology, Karolinska University Hospital Solna, SE-171 76 Stockholm, SWEDEN. E-mail: hans.jacobsson{at}karolinska.se

Background: A negative effect of soft drinks, especially phosphate containing colas, on bone mineral contents has been reported. Most studies have been epidemiological investigations or performed in healthy humans.

Objective: The aim was to study the effect of short-time ingestion of Coca-Cola®, a phosphate containing soft drink, and of Fanta®, a non-phosphate containing soft drink, in a murine system for bone scintigraphy. This technique may be used to study bone metabolism.

Design and Methods: After feeding the beverages to the mice during different time periods (2 h to 6 days), the animals were injected with the bone-seeking radiopharmaceutical. The activity distribution was thereafter mapped by dissecting the hind legs and different soft tissue organs and assessing their activity with a gamma-counter. Controls were mice drinking water.

Results: After drinking Coca-Cola® there was a significantly increased bone uptake of the tracer and a reduced uptake by most soft tissues versus controls. After Fanta® there were no differences. Comparing Coca-Cola® and Fanta®, there was a significantly lower uptake by all soft tissues after Coca-Cola®, but no significant difference for bone.

Conclusions: Short-time ingestion of Coca-Cola® in mice causes an increased bone uptake and a reduced soft tissue uptake at bone scintigraphy. There may be a similar, weaker effect by Fanta®. This is in agreement with previous studies indicating that soft drinks may, on their own, have a metabolic effect on the bone.

Key words: bone scintigraphy, osteoporosis, phosphoric acid, mouse, soft drink

Abbreviations: 99Tcm-DPD = dicarboxypropane diphosphonate • 99Tcm-HDP = hydroxymethylene diphosphonate






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