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Journal of the American College of Nutrition, Vol. 27, No. 4, 470-475 (2008)
Published by the American College of Nutrition

Effect of Muesli with 4 g Oat β-Glucan on Postprandial Blood Glucose, Gastric Emptying and Satiety in Healthy Subjects: A Randomized Crossover Trial

Joanna Hlebowicz, MD, Gassan Darwiche, MD, PhD, Ola Björgell, MD, PhD and Lars-Olof Almér, MD, PhD

Department of Medicine (J.H., G.D., L.-O.A.)
Department of Radiology (O.B.), Malmö University Hospital, University of Lund, Malmö, SWEDEN

Address reprint requests to: Dr. Joanna Hlebowicz, Dept. of Medicine, Malmö University Hospital, Entrance 35, 205 02 Malmö, SWEDEN. E-mail: Joanna.Hlebowicz{at}med.lu.se

Objective: Products enriched with oat β-glucan have been shown to reduce postprandial glucose and insulinemic responses. The aim of this study was to evaluate the effect of an extruded muesli product based on oat β-glucan on the rate of gastric emptying, postprandial blood glucose and satiety in healthy subjects.

Methods: Gastric emptying rate (GER) was measured by standardized real-time ultrasonography. Twelve healthy subjects were assessed using a randomized crossover double blind trial. The meals were administered after 8 hours’ fasting after measuring the subject's normal fasting blood glucose level. Blood glucose measurements were made before, 30 and 60 min after the end of the meal. Satiety scores were estimated 15 and 90 min after the end of the meal. The GER was calculated as the percentage change in the antral cross-sectional area 15 and 90 minutes after ingestion of vanilla yoghurt with muesli containing 4 g oat β-glucan (GER1) or vanilla yoghurt with muesli containing cornflakes (GER2).

Results: The median values were 60% for GER1 and 44% for GER2. The effect of 4 g oat β-glucan on the rate of gastric emptying was not statistically significant compared with corn flakes. Muesli with 4 g oat β-glucan lowered the postprandial glucose response significantly compared to the cornflakes meal (p = 0.045). The effect of oat β-glucan on satiety was not statistically significantly.

Conclusions: The results of this study suggest that intake of muesli with 4 g oat β-glucan does not affect the gastric emptying rate or satiety but lowers the postprandial blood glucose response, indicating that the GER does not regulate the blood glucose level.

Key words: gastric emptying, blood glucose, healthy subjects, oat, β-glucan, satiety

Abbreviations: AUC = areas under the curve • GER = gastric emptying rate • GI = glycemic-index • Min = minimum • Max = maximum • q1 = the first quartile • q3 = the third quartile






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