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Journal of the American College of Nutrition, Vol. 28, No. 2, 177-183 (2009)
Published by the American College of Nutrition

Zinc Absorption Adapts to Zinc Supplementation in Postmenopausal Women

Jeannemarie M. Beiseigel, PhD, Leslie M. Klevay, MD, LuAnn K. Johnson, MS and Janet R. Hunt, PhD

US Department of Agriculture-Agricultural Research Service Grand Forks Human Nutrition Research Center (J.R.H., J.M.B., L.M.K.)
University of North Dakota (L.K.J.), Grand Forks, North Dakota

Address correspondence to: JR Hunt, US Department of Agriculture, ARS, GFHNRC, University of North Dakota, PO Box 9034, Grand Forks, ND 58202-9034. E-mail: janetrhunt{at}gmail.com

Objective: To determine if human Zn absorption adapts to chronic high Zn intakes.

Methods: Zn absorption was measured at 0, 8, and 16 wk in healthy postmenopausal women who consumed controlled diets with ~5 mg Zn from food, supplemented to 14 (n = 6), 32 (n = 3), or 47 (n = 3) mg Zn/d for 22 wk. Zn absorption for 1 day was determined by 65Zn-labeling of meals and whole body scintillation counting.

Results: At wk 0, less Zn was absorbed from diets with 14, compared with 32 or 47 mg/d (4.6, 8.7, and 10.3 mg/d, respectively; pooled SE = 0.9; p < 0.05). These differences were not apparent at wk 8 (5.4, 5.8, 6.4; NS) and became negligible by wk 16 (5.0, 5.0, 5.1; NS). Plasma Zn concentrations were unaffected. The results are consistent with a saturation response model of Zn absorption.

Conclusion: Within several weeks, postmenopausal women biologically adapted to absorb a relatively uniform amount of 5 mg Zn/d when controlled, Zn-supplemented diets supplied consistent Zn intakes between 14 and 47 mg/d.

Key words: zinc, zinc supplementation, zinc absorption, plasma zinc






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