Journal of the American College of Nutrition, Vol 9, Issue 5 503-509, Copyright © 1990 by American College of Nutrition

JOURNAL ARTICLE

Excess vitamin A injures the liver

H. Baker, W. ten Hove, N. Kanagasundaram, G. Zaki, C. B. Leevy, O. Frank and C. M. Leevy
Department of Medicine, New Jersey Medical School, Newark.

Chronic vitamin A intoxication in a 56-year-old female is reported. Some abnormal blood chemistries included elevated transaminase and alkaline phosphatase, increased cerebrospinal fluid and portal pressure, and elevated vitamin A in blood and liver. A liver biopsy indicated histologic evidence of perisinusoidal collagen deposition and noncoalescent fat droplets in Ito cells. Caution against the misdiagnosis of alcoholic cirrhosis for vitamin A intoxication is recommended.

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