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Fibromyalgia—A Hidden Link?

Barbara A. Monroe, MS, RD, CNSD

Nutrition Department
Spaulding Rehabilitation Hospital
Boston, MA



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  		Fig. 1. Nutritional factors impairing B1 metabolism include mainly alcohol or excessive intake of carbohydrates. Transketolase (B1 dependent) abnormalities induce pentose pathway impairment and nicotinamide adenosine dinucleotide phosphate reduced (NADPH) deficit. NADPH is involved in reduced glutathione (GSH) and nitric oxid (NO) synthesis and therefore in muscle microcirculation and antioxidant defenses. Pyruvate dehydrogenase (B1 dependent) abnormalities induce adenosine triphosphate (ATP) deficit. ATP is involved in phosphorylations (peculiarly B1 activation) and performances. Thiamin deficiency is associated with brain serotonin depletion. Serotonin is involved in pain perception, mood and nutritional habits. It is noteworthy that pain and fatigue induce detraining that aggravates these metabolic abnormalities.

Details in reference 6 and 10.

 




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