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Chromium, Glucose Intolerance and Diabetes

Richard A. Anderson, PhD, FACN

Nutrient Requirements and Functions Laboratory, Beltsville Human, Nutrition Research Center, US Department of Agriculture, ARS, Beltsville, Maryland



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  		Fig. 1. Mode of action of Cr in potentiation of insulin. Cr increases insulin binding to cells by increasing insulin receptor number. Cr also increases insulin sensitivity by increasing insulin receptor phosphorylation. Cr potentiation of insulin is inhibited by wortmanin, which inhibits the enzyme, PI 3-kinase (phosphotidylinositol 3'-kinase).

 




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