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Carnitine Increases Glucose Disposal in Humans

Andrea De Gaetano, MD, PhD (Math), Geltrude Mingrone, MD, PhD, FACN, Marco Castagneto, MD, FACS and Menotti Calvani, MD, PhD,

Consiglio Nazionale delle Ricerche, Centro Fisiopatologia Shock, Laboratorio di Biomatematica (A.D.G., M.C.), Rome, ITALY
Istituto di Clinica Medica, Universita' Cattolica del Sacro Cuore (G.M., M.C.), Rome, ITALY



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Fig. 1. Time/concentration data points and fitted model curves for blood glucose in experimental subject #9. Lines are predicted concentrations; points are observed values.

 


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Fig. 2. Time/concentration data points and fitted model curves for blood insulin in experimental subject #9.

 


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Fig. 3. Time/concentration data points and fitted model curves for blood C-peptide in experimental subject #9.

 


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Fig. 4. Group averages and standard errors (I-bars) for RQ during successive time periods. Shaded: placebo; hollow: carnitine. Significant differences between placebo and carnitine at (0–30') and at (30–60').

 


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Fig. 5. Group averages and standard errors (I-bars) for EE during successive time periods. Shaded: placebo; hollow: carnitine. No significant differences between placebo and carnitine.

 


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Fig. 6. Group averages and standard errors (I-bars) for NEFA (as % of baseline level) during successive time periods. Shaded: placebo; hollow: carnitine. Significant differences between placebo and carnitine at 6', 25' and 100'.

 





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