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Effects of Dietary -3 and -6 Lipids and Vitamin E on Serum Cytokines, Lipid Mediators and Anti-DNA Antibodies in a Mouse Model for Rheumatoid Arthritis

Department of Physical Therapy, Exercise and Nutrition Sciences, State University of New York at Buffalo, 15 Farber Hall, Buffalo, New York

View larger version (29K): [in a new window]   Fig. 1. Effects of dietary lipids and vit-E on body weights of MRL/lpr and MRL/++ mice. Values are Mean±SEM, n=10 mice/group, CO: Corn oil: FO: Fish oil; vit-E-75 IU and vit-E-500 IU refer to vit-E levels/kg diet.

View larger version (56K): [in a new window]   Fig. 2. Effects of dietary lipids and vit-E on body weight gain of MRL/lpr and MRL/++ mice. Values are Mean±SEM, n=10 mice/group. Means with different superscripts are significantly different at p<0.05 as revealed by Fisher’s PLSD test; CO: Corn oil; FO: Fish oil; vit-E-75 IU and vit-E-500 IU refer to vit-E levels/kg diet.

View larger version (32K): [in a new window]   Fig. 3. Effects of dietary lipids and vit-E on serum anti-dsDNA levels in MRL/lpr and MRL/++ mice. (3a. Titration curve, the differences between the two groups were statistically significant; 3b. Effects of strain and diets). Values are Mean±SEM, n=8–10 mice/group. Means with different superscripts are significantly different at p<0.05 as revealed by Fisher’s PLSD test; CO: Corn oil; FO: Fish oil; vit-E-75 IU and vit-E-500 IU refer to vit-E levels/kg diet.

View larger version (51K): [in a new window]   Fig. 4. Effects of dietary lipids and vit-E on serum IL-2 and IFN-g levels in MRL/lpr and MRL/++ mice. Values are Mean±SEM, n=10 mice/group. Means with different superscripts are significantly different at p<0.05; CO: Corn oil; FO: Fish oil; vit-E-75 IU and vit-E-500 IU refer to vit-E levels/kg diet.

View larger version (37K): [in a new window]   Fig. 5. Effects of dietary lipids and vit-E on serum IL-4, IL-10 and IL-12 levels in MRL/lpr and MRL/++ mice. Values are Mean±SEM, n=8–10 mice/group. Means with different superscripts are significantly different at p<0.05; CO: Corn oil; FO: Fish oil; vit-E-75 IU and vit-E-500 IU refer to vit-E levels/kg diet.

View larger version (35K): [in a new window]   Fig. 6. Effects of dietary lipids and vit-E on serum IL-1ß, IL-6 and TNF- levels in MRL/lpr and MRL/++ mice. Values are Mean±SEM, n=8–10 mice/group. Means with different superscripts are significantly different at p<0.05; CO: Corn oil; FO: Fish oil; vit-E-75 IU and vit-E-500 IU refer to vit-E levels/kg diet.

View larger version (50K): [in a new window]   Fig. 7. Effects of dietary lipids and vit-E on serum lipid mediators (PGE2, LTB4 and TXB2) levels in MRL/lpr and MRL/++ mice. Values are Mean±SEM, n=8–10 mice/group. Means with different superscripts are significantly different at p<0.05; CO: Corn oil; FO: Fish oil; vit-E-75 IU and vit-E-500 IU refer to vit-E levels/kg diet.