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Body Weight and Prior Depletion Affect Plasma Ascorbate Levels Attained on Identical Vitamin C Intake: A Controlled-Diet Study

Gladys Block, PhD, Ann R. Mangels, PhD, Blossom H. Patterson, PhD, Orville A. Levander, PhD, Edward P. Norkus, PhD and Philip R. Taylor, MD, ScD

National Cancer Institute (G.B., B.H.P., P.R.T.), Bethesda;
USDA Agricultural Research Center, Beltsville (A.R.M., O.A.L.), Maryland;
Our Lady of Mercy Medical Center, Bronx, New York (E.P.N.)



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  		Fig. 1. Plot of relationship between vitamin C dose per kg of total body weight and area under the repletion curve, first repletion cycle, n=68 men, r=0.66. Association of dose per kg of lean body mass with AUC is lower, r=0.57.

 


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  		Fig. 2. 2a. Plasma AA of each of the 68 study participants, over the course of the study.

2b. Mean plasma AA over the course of the study, within quartiles of body weight. Q1 (quartile 1) comprised persons in the lightest body weight quartile, range 59.3–71.3 kg; Q2, range 72.2–81.4 kg; Q3, range 81.5–90.9 kg; Q4 comprised persons in the heaviest quartile of body weight, range 91.5–100.8 kg. Mean area under the curve was different between the first and fourth body weight quartiles (p<0.0001), first and third (p<0.0001) and first and second body weight quartiles (p<0.006).

2c. Even within a single quartile of body weight, however, individual variability remains. Plasma AA of the 17 study participants in body weight quartile 3, over the course of the study.

 




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