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Influence of Purine Intake on Uric Acid Excretion in Infants Fed Soy Infant Formulas

Matthew J. Kuchan, PhD, Karin M. Ostrom, PhD, Carla Smith, BS and Peter E. Hu, PhD

Pediatric Clinical Nutrition Research, Medical and Regulatory Affairs (M.J.K., K.M.O., P.E.H.) Ross Products Division of Abbott Laboratories, Columbus, Ohio
Analytical Research and Development (C.S.), Ross Products Division of Abbott Laboratories, Columbus, Ohio



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Fig. 1. Serum uric acid concentration in infants fed different infant formulas or human milk. The data result from 4 separate trials as indicated by the shading. Trial A, {blacksquare}; infants were enrolled from birth to 8 days of age (Isomil with Iron, experimental soy formula with supplemental nucleotides 72 mg/L, human milk; n=20/group). Trial B, ; infants were enrolled from birth to 14 days of age and were fed Similac with Iron supplemented with nucleotides 72 mg/L (n=23). Trial C,; infants were enrolled from birth to 2 days of age [human milk, n=19; Similac with Iron not supplemented with nucleotides, n1=20 and n2=18 (same formula supplemented with calcium), and Enfamil with Iron, n=20]. Trial D, {square}; infants were enrolled between birth and 8 days of age and fed Similac with Iron not supplemented with nucleotides (n=22). Values represent mean ± SEM. Means values generated within trials were compared statistically, however, comparisons were not done across the trials constituting this Study. * No differences were detected between the groups in trial C. {dagger}{ddagger} Means from trial A with different symbols differed, p<0.0001. Dashed lines indicate reference standards for infants 1 to 3 months of age [19].

 


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Fig. 2. Urinary uric acid output in infants fed the two study formulas. Complete 72 hour urine collections were analyzed for uric acid and the average output per 24 hours calculated. Each symbol indicates the result of one balance study with results in the same infant connected by lines. Output was higher (p=0.006) while subjects were fed the STD Purine formula compared to when the subjects were fed the Reduced Purine formula.

 


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Fig. 3. Urinary uric acid excretion in infants fed the two study formulas. Spot urine collections were done at 28 and/or 56 days of age and the average excretion as a ratio of creatinine concentration calculated. Each symbol represents a subject and at least one uric acid measurement. Bars indicate group means, which differed, p=0.0001.

 





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