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Systemic Immunity-Enhancing Effects in Healthy Subjects Following Dietary Consumption of the Lactic Acid Bacterium Lactobacillus rhamnosus HN001

Ying-H. Sheih, MD, Bor-L. Chiang, MD, Ling-H. Wang, MD, Chuh-K. Liao, MD and Harsharnjit S. Gill, PhD

Taipei Medical College Hospital (Y.-H.S., C.-K.L.), Taipei, Taiwan
College of Medicine, National University of Taiwan (B.-L.C., L.-H.W.), Taipei, Taiwan
Milk & Health Research Centre, Massey University (H.S.G.), Palmerston North, New Zealand



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  		Fig. 1. Flow-chart outlining the trial design and timing of immune measurements.

 


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  		Fig. 2. Effect of dietary consumption of milk or L. rhamnosus HN001-supplemented milk on PMN cell phagocytic activity. Group A: L. rhamnosus HN001 in LFM between weeks 3 and 6. Group B: L. rhamnosus HN001 in LFM-LH between weeks 3 and 6. Healthy adult and elderly subjects consumed low-fat milk for 3 weeks, followed by milk supplemented with L. rhamnosus HN001 for 3 weeks, before returning to non-supplemented low-fat milk for the final 3 weeks of the trial. Immune measurements were taken at the start of the trial (week 0), after 3 weeks’ consumption of LFM (week 3), after 3 weeks’ consumption of L. rhamnosus HN001 in LFM (upper graph) or L. rhamnosus HN001 in lactose-hydrolyzed LFM (lower graph) (week 6) and after 3 weeks’ return to non-supplemented LFM (week 9). Data refer to mean (+ standard deviation) percentages of PMN cells displaying NBT reduction activity at each time point.*=significantly higher levels of phagocytic activity in comparison to respective values at week 0 or week 3 (p < 0.01).

 


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  		Fig. 3. Effect of dietary consumption of milk or L. rhamnosus HN001-supplemented milk on NK cell tumor killing activity. Group A: L. rhamnosus HN001 in LFM between weeks 3 and 6. Group B: L. rhamnosus HN001 in LFM-LH between weeks 3 and 6. Healthy adult and elderly subjects consumed low-fat milk for 3 weeks, followed by milk supplemented with L. rhamnosus HN001 for 3 weeks, before returning to non-supplemented low-fat milk for the final 3 weeks of the trial. Immune measurements were taken at the start of the trial (week 0), after 3 weeks’ consumption of LFM (week 3), after 3 weeks’ consumption of L. rhamnosus HN001 in LFM (upper graph) or L. rhamnosus HN001 in lactose-hydrolyzed LFM (lower graph) (week 6) and after 3 weeks’ return to non-supplemented LFM (week 9). Data refer to mean (+ standard deviation) percentages of specific target cell lysis at each time point.*=significantly higher levels of killing activity in comparison to respective values at week 0 or week 3 (p < 0.01).

 




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