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Constructive Interactions among Nutrients and Bone-Active Pharmacologic Agents with Principal Emphasis on Calcium, Phosphorus, Vitamin D and Protein

Robert P. Heaney, MD

John A. Creighton University Professor, Creighton University, Omaha, Nebraska



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Fig. 1. Change in bone mineral density at three skeletal sites with estrogen replacement in postmenopausal women, both with and without supplemental calcium. (Redrawn from the meta-analysis of Nieves et al. [17]; copyright Robert P Heaney, 2000. Used with permission.)

 


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Fig. 2. Bone mineral density change on low dose estrogen regimens reported from five studies [1822]. The bottom two trials used neither supplemental calcium nor vitamin D; the third and fourth trials up used calcium only, and the top trial used both supplemental calcium and vitamin D. (Copyright Robert P Heaney, 2000. Used with permission.)

 


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Fig. 3. Change in bone mineral density plotted by quartile of calcium intake. (Redrawn from the data of Hannan et al. [31]; Copyright Robert P. Heaney, 2000. Used with permission).

 





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