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D-Alpha-Tocopheryl Succinate (Vitamin E) Enhances Radiation-Induced Chromosomal Damage Levels in Human Cancer Cells, but Reduces it in Normal Cells

Center for Vitamins and Cancer Research, Department of Radiology, University of Colorado Health Sciences Center, Denver (B.K., W.C., K.P.), Colorado
Department of Radiological Health Sciences, Colorado State University, Fort Collins (M.N.J., J.S.B.), Colorado

View larger version (26K): [in a new window]   Fig. 1. Effect of d--tocopheryl succinate (-TS) on the level of radiation-induced chromosomal damage in human cervical cancer (HeLa cells), ovarian carcinoma cell lines (OVG1 and SKOV3) and in human normal skin fibroblasts (GM2149, HF19 and AG1522). -TS treatment alone increased chromosomal damage in all three cancer cell lines, but not in any normal cell lines. -TS treatment also enhanced the levels of radiation-induced chromosomal damage in cancer cells but it protected normal cells against such damage. The bar is standard error of the mean; the difference between control and experimental groups in cancer cells, and between control (irradiation alone) and experimental groups (irradiation plus -TS) is significant at p < 0.05.