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Potentiation of the Effect of Paclitaxel and Carboplatin by Antioxidant Mixture on Human Lung Cancer H520 Cells

Department of Medical Oncology, Institute Rotary Cancer Hospital (A.K.P., V.K.), All India Institute of Medical Sciences, New Delhi INDIA
Department of Biochemistry (N.S., N.K., V.G.R.), All India Institute of Medical Sciences, New Delhi INDIA
Center for Vitamin and Cancer Research, University of Colorado Health Sciences Center, Denver, Colorado (K.N.P.)

View larger version (31K): [in a new window]   Fig. 1. Flow-cytometric analysis of the effect of combination of the agents (paclitaxel, carboplatin and antioxidant mixture) on apoptosis in H520 cells. Cells were treated as described in Table 3. Shown are the histograms of a representative experiment. a) control, b) paclitaxel and carboplatin simultaneously, c) paclitaxel followed 24 hours later by carboplatin, d) antioxidant mixture and paclitaxel simultaneously followed 24 hours later by carboplatin, e) antioxidant mixture followed 24 hours later by paclitaxel and 48 hours later by carboplatin.