HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Huynh, N. T. Articles by Tayek, J. A. Search for Related Content PubMed PubMed Citation Articles by Huynh, N. T. Articles by Tayek, J. A.

Oral Arginine Reduces Systemic Blood Pressure in Type 2 Diabetes: Its Potential Role in Nitric Oxide Generation

Department of Internal Medicine, Harbor-UCLA Medical Center, UCLA School of Medicine, Torrance, California

View larger version (28K): [in a new window]   Fig. 1. This figure demonstrates the mean plasma arginine concentration with or without oral arginine supplements.

View larger version (27K): [in a new window]   Fig. 2. This figure demonstrates the mean ornithine with or without oral arginine supplements. There was a significant difference by ANOVA (p < 0.01) and a significant increase over time (p < 0.05).

View larger version (28K): [in a new window]   Fig. 3. This figure demonstrates the mean citrulline concentration while taking oral arginine supplements. The mean difference between the arginine and the non-arginine ingestion day was significant (p < 0.05). Individual determinations at each time point resulted in significant differences at time 10:00 and 12:00 after correction for multiple comparisons (p < 0.05).

View larger version (30K): [in a new window]   Fig. 4. This figure demonstrates the hourly mean systolic blood pressure (mean ± SEM) in volunteers with or without oral arginine supplements. ANOVA testing demonstrated a significant difference during the treatment period (Hour 5:00 to Hour 14:00, i.e., 5:00 AM to 2:00 PM). The effect of arginine on systolic blood pressure was not significant until 7:00 AM. There was no difference between groups after arginine was discontinued (Hours 15:00 and 16:00). Please note that the arginine was stopped at hour 14:00 or 2:00 PM. The hypotensive influence was not present one hour after stopping the arginine for systolic measurements. A significant difference between the two groups at each time point by paired testing is indicated by a star (p < 0.05).

View larger version (35K): [in a new window]   Fig. 5. This figure demonstrates the hourly mean diastolic blood pressure in volunteers with or without oral arginine supplements. ANOVA testing demonstrated a significant difference during the treatment period (Hour 5:00 to Hour 14:00, i.e., 5:00 AM to 2:00 PM). There was no difference between groups after arginine was discontinued (Hour 15:00, 16:00 and 24:00 or 0:00). Please note that the arginine was stopped at hour 14:00 or 2:00 PM. The hypotensive influence was not present one hour after stopping the arginine. Significant difference between the two groups at each time point by paired testing is indicated by a star (p < 0.05).