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Hypothesis: Vitamin E Complements Polyunsaturated Fatty Acids in Essential Fatty Acid Deficiency in Cystic Fibrosis

Discipline of Nutrition and Dietetics, University of Newcastle, Callaghan (L.G.W., M.L.G.), New South Wales, AUSTRALIA
Department of Respiratory Medicine, The Children’s Hospital at Westmead, Sydney (D.A.F.),New South Wales, AUSTRALIA

View larger version (12K): [in a new window]   Fig. 1. Plasma vitamin E concentration in 21 stable CF patients versus 21 age and gender matched healthy controls. None of the participants had used vitamin supplements within the previous four weeks. The figure is based on previously published data [19]. p < 0.001.

View larger version (13K): [in a new window]   Fig. 2. %PUFA in erythrocyte membranes versus plasma vitamin E concentration in 21 CF patients. Data is non-parametric and analyzed using Spearman’s rank coefficient. r = 0.427, p = 0.05.

View larger version (13K): [in a new window]   Fig. 3. plasma PUFA concentration versus plasma vitamin E concentration following antioxidant supplementation. Data is normally distributed and analyzed using Pearson’s correlation coefficient. r = 0.544, p = 0.009.

View larger version (22K): [in a new window]   Fig. 4. Factors determining membrane EFA status.