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Effect of Dietary n-3 and n-6 Oils with and without Food Restriction on Activity of Antioxidant Enzymes and Lipid Peroxidation in Livers of Cyclophosphamide Treated Autoimmune-Prone NZB/W Female Mice

Department of Medicine, Division of Clinical Immunology, University of Texas Health Science Center, San Antonio, Texas

View larger version (35K): [in a new window]   Fig. 1. Effect of dietary lipids and food restriction on liver catalase activity in cyclophosphamide treated and untreated mice. Values (mean ± SEM, 3–5 mice/group) with different superscripts are significantly different at p < 0.05. CO = corn oil, FO = fish oil, CTX = cyclophosphamide, AL = ad libitum, FR = food restriction.

View larger version (39K): [in a new window]   Fig. 2. Effect of dietary lipids and food restriction on liver superoxide dismutase activity in cyclophosphamide treated and untreated mice. Values (mean ± SEM, 3–5 mice/group) with different superscripts are significantly different at p < 0.05. CO = corn oil, FO = fish oil, CTX = cyclophosphamide; AL = ad libitum, FR = food restriction.

View larger version (40K): [in a new window]   Fig. 3. Effect of dietary lipids and food restriction on liver glutathione peroxidase activity in cyclophosphamide treated and untreated mice. Values (mean ± SEM, 3–5 mice/group) with different superscripts are significantly different at p < 0.05. CO = corn oil, FO = fish oil, CTX = cyclophosphamide, AL = ad libitum, FR = food restriction.

View larger version (40K): [in a new window]   Fig. 4. Effect of dietary lipids and food restriction on liver glutathione transferase activity in cyclophosphamide treated and untreated mice. Values (mean ± SEM, 3–5 mice/group) with different superscripts are significantly different at p < 0.05. CO = corn oil, FO = fish oil, CTX = cyclophosphamide, AL = ad libitum, FR = food restriction.

View larger version (26K): [in a new window]   Fig. 5. Effect of dietary lipids and food restriction on liver TBARS generation in cyclophosphamide treated and untreated mice. Values (mean ± SEM, 3–5 mice/group) with different superscripts are significantly different at p < 0.05. CO = corn oil, FO = fish oil, CTX = cyclophosphamide, AL = ad libitum, FR = food restriction.

View larger version (23K): [in a new window]   Fig. 6. Effect of dietary lipids and food restriction on serum anti-dsDNA antibody levels in cyclophosphamide treated and untreated mice. Values (mean ± SEM, 3–5 mice/group) with different superscripts are significantly different at p < 0.05. CO = corn oil, FO = fish oil, CTX = cyclophosphamide, AL = ad libitum, FR = food restriction.