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Anti-TNF- Antibody Normalizes Serum Leptin in IL-2 Deficient Mice

Department of Nutrition and Food Science, University of Kentucky, and the Lexington Veterans Administration Medical Center, Lexington (L. M. G.)
Department of Internal Medicine University of Louisville, Louisville (H. S. O., C. J. M.), Kentucky
Department of Internal Medicine, Bristol-Myers Squibb, Lawrenceville Campus, Princeton, New Jersey (R. C. F.)

View larger version (27K): [in a new window]   Fig. 1. Serum TNF- concentrations for interleukin-2 deficient (IL-2-/-) (n = 6) and wild-type control (IL-2+/+) (n = 6) male mice in the fed state and after 24 hours of starving at 10 weeks of age. Values are the means ± SEM. Means in the same nutritional state (fed, starved) and between nutritional states with a different letter differ, p < 0.05 (ANOVA and subsequent Fisher’s protected least significant difference test).

View larger version (25K): [in a new window]   Fig. 2. Changes in serum leptin concentrations in the fed state and after 24 hours of starving for interleukin-2 deficient (IL-2-/-) and wild-type control (IL-2+/+) male mice (10 weeks old) divided into four groups, IL-2-/- (n = 6) and controls (n = 6), each that received anti-TNF- antibody and IL-2-/- (n = 6), and controls (n = 6), each that did not receive anti-TNF- antibody in the fed state. Values are the means ± SEM. Means in the same nutritional state (fed, starved) with a different letter differ, p < 0.05, and all groups between fed and starved state had significant changes, p < 0.05 (ANOVA and subsequent Fisher’s protected least significant difference test).