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Insulin Clearance in Obesity

M. Elena Valera Mora, MD, Antonino Scarfone, MD, Menotti Calvani, MD, Aldo V. Greco, MD and Geltrude Mingrone, MD, PhD

Institute of Internal Medicine, Catholic University of Rome, Rome (M.E.V.M., A.S., A.V.G., G.M.), ITALY
Sigma Tau Pharmaceuticals, Pomezia (M.C.), ITALY



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  		Fig. 1. The acidification of the endosomal lumen, due to the presence of proton pumps, results in dissociation of insulin from its receptor and the action of IDE leads to a production of multiple end-products.

 




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