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Null and Opposing Effects of Asian Ginseng (Panax ginseng C.A. Meyer) on Acute Glycemia: Results of Two Acute Dose Escalation Studies

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Clinical Nutrition and Risk Factor Modification Centre, St. Michael’s Hospital (J.L.S., L.A.L., V.V.), Toronto, CANADA
Department of Biology, Faculty of Science, University of Ottawa, Ottawa (J.T.A.), CANADA

View larger version (19K): [in a new window]   Fig. 1. The aggregate acute treatment effect of Asian ginseng on plasma glucose and insulin for two studies. The line plots and bars represent the incremental and AUC plasma glucose and insulin responses following the mean of two placebos (3 g and 9 g) (•) or the mean of doses from 1–9 g (1–3 g and 3–9 g) () taken 40 minutes before a 75 g oral glucose tolerance test (75 g-OGTT) in two studies each with 11 healthy, nondiabetic participants, in which each subject did all treatments in a single-blinded, randomized, multiple crossover design. Data are mean ± SEM.

View larger version (40K): [in a new window]   Fig. 2. Acute dose effects of Asian ginseng over a 1–9 g dose range on plasma glucose and insulin in two studies: (A) Study 1—the line plots and bars represent the incremental change and AUC for plasma glucose and insulin following placebo () or doses of 1 g (), 2 g (), or 3 g () of Asian ginseng taken 40 minutes before a 75 g oral glucose tolerance test (75 g-OGTT) in 11 healthy, nondiabetic participants, in which each subject did all treatments in a single-blinded, randomized, multiple crossover design. (B) Study 2—the line plots and bars represent the incremental change and AUC for plasma glucose and insulin following placebo (•) or doses of 3 g (), 6 g (), or 9 g () of Asian ginseng taken 40 minutes before a 75 g oral glucose tolerance test (75 g-OGTT) in 11 healthy, nondiabetic participants, in which each subject did all treatments in a single-blinded, randomized, multiple crossover design. Data are mean ± SEM.