HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kim, S.-Y. Articles by Lee, S.-J. Search for Related Content PubMed PubMed Citation Articles by Kim, S.-Y. Articles by Lee, S.-J.

Protective Effects of Dietary Soy Isoflavones against UV-Induced Skin-Aging in Hairless Mouse Model

Pharmaceutical & Health Research Institute, AmorePacific Corporation R&D Center, Yongin, Kyounggi, KOREA

View larger version (65K): [in a new window]   Fig. 1. Top (1A): Skin replicas for (a) age-matched, normal mouse skin, (b) UV-irradiated control mouse skin and (c) UV irradiated mouse skin given with isoflavones. Bottom (1B): Evaluation of the microrelief of UV-damaged skin in hairless mice and age-matched non-irradiated mice. The results are expressed as Mean values ± SD for parameters Rz, Ra, Rm and Rt. Values not sharing the same letter are significantly different, p < 0.05.

View larger version (52K): [in a new window]   Fig. 2. Top (2A): Hematoxylin & Eosin (H&E) staining of UV-irradiated mouse skin: (a) age-matched, normal mouse skin, (b) UV irradiated control mouse skin and (c) UV irradiated mouse skin given with isoflavones. (Scale bar = 30 µm.) Bottom (2B): Effects of UV irradiation on the epidermal thickness. The mice were UV-irradiated three times per week for four weeks as described in Materials and Methods. The epidermal thickness was measured on the H & E stained sections. The results are expressed as a mean ± SD of the thickness in µm. Values not sharing the same letter are significantly different, p < 0.05.

View larger version (52K): [in a new window]   Fig. 3. Immunohistological stains for type 1 procollagen (a) age-matched, normal mouse skin, (b) UV-irradiated control mouse skin and (c) UV-irradiated, isoflavone administrated mouse skin. (Scale bar = 50 µm.)

View larger version (15K): [in a new window]   Fig. 4. Inhibition of UVB-induced collagenase secretion by the isoflavones in the fibroblasts. The cells were irradiated with UVB (15 mJ/cm2) and treated with the isoflavones (1 ppm, 10 ppm). Three independent experiments were performed to determine the levels of MMP-1. The asterisk indicates the values significantly different from the UVB-irradiated control group, as determined by the two-tailed t test (p < 0.05).