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Magnesium Attenuates Post-Traumatic Depression/Anxiety Following Diffuse Traumatic Brain Injury in Rats

Lisa Fromm, B Pharm, Deanne L. Heath, PhD, Robert Vink, PhD and Alan J. Nimmo, PhD

School of Pharmacy and Molecular Sciences, James Cook University, Townsville, QLD (L.F., D.L.H., A.J.N.), AUSTRALIA
Department of Pathology, University of Adelaide, Adelaide SA (R.V.), AUSTRALIA



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Fig. 1. Open field-testing over a six-week period following traumatic brain injury in rats. There was a significant decline (p < 0.001) in open field activity after injury, with a return to pre-injury levels only observed in the magnesium treated group. * = p < 0.05 versus controls.

 


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Fig. 2. Incidence of depression over a six-week period following traumatic brain injury in rats. There was a significant increase (p < 0.001) in the incidence of depression after injury, with the magnesium treated animals having a decreased incidence relative to controls, particularly at later time points. * = p < 0.05 versus controls.

 





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