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A Substance P Antagonist Increases Brain Intracellular Free Magnesium Concentration after Diffuse Traumatic Brain Injury in Rats

Robert Vink, PhD, J. J. Donkin, M. I. Cruz, Alan J Nimmo, PhD and Ibolja Cernak

Department of Pathology, University of Adelaide, Adelaide SA (R.V., J.J.D.), AUSTRALIA
School of Pharmacy and Molecular Sciences, James Cook University, Townsville QLD (A.J.N., I.C.), AUSTRALIA
Department of Neuroscience, Georgetown University, Washington DC (M.I.C.)



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  		Fig. 1. Brain intracellular free Mg concentration prior to and 4 hrs following severe diffuse traumatic brain injury in rats. Animals were administered n-acetyl tryptophan (NAT, substance P antagonist) or equal volume saline at 30 minutes after induction of injury. * p < 0.05.

 




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