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Development of Cellular Magnesium Nano-Analysis in Treatment of Clinical Magnesium Deficiency

University of Louisville, School of Medicine, Department of Physiology & Biophysics, Louisville, Kentucky (Ret), and IntraCellular Diagnostics, Inc., Foster City, California

View larger version (20K): [in a new window]   Fig. A. Intracellular analysis.

View larger version (80K): [in a new window]   Fig. 1. Destructive calcium crystals after infarct; no magnesium given (left panel). No destructive crystals after infarct; magnesium given prior to infarct (right panel).

View larger version (14K): [in a new window]   Fig. 2. Correlation of atrial and sublingual [Mg]i. Atrial biopsy tissues frozen at surgery. Sublingual tissues taken within 8 hours of surgery or at surgery.

View larger version (56K): [in a new window]   Fig. 3. Increase of intracellular Mg in MI patients following Mg infusion from admission through 48 hours post-treatment.

View larger version (25K): [in a new window]   Fig. 4. QT dispersion and change in sublingual intracellular magnesium (EXAtest) in 12 patients having two measurements 3 to 7 days apart.

View larger version (10K): [in a new window]   Fig. 5. Comparison of [Mg2+] from cardiac myocytes and [Mg]i in sublingual cells from pacing-induced heart failure in dogs.

View larger version (39K): [in a new window]   Fig. 6. Intracellular Mg2+ concentrations for normal and CHF dogs.

View larger version (22K): [in a new window]   Fig. 7. Correlation of percent change in baseline brachial artery flow-mediated vasodilation (%FMD) and baseline intracellular lever, ([Mg]i), in 50 subjects showing a linear correlation.

View larger version (19K): [in a new window]   Fig. 8. Percent change in endothelium-dependent brachial artery flow-mediated vasodilation (%FMD) in placebo (horizontal line) (n = 25) and magnesium (diagonal line) (n = 25) at baseline and after 6 months.

View larger version (18K): [in a new window]   Fig. 9. Correlation of [Mg]i and exercise duration.

View larger version (18K): [in a new window]   Fig. 10. Exercise duration after Mg and placebo.