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Nutritional Importance of Choline for Brain Development

Steven H. Zeisel, MD, PhD

Department of Nutrition, School of Public Health, School of Medicine, University of North Carolina, Chapel Hill, North Carolina



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  		Fig. 1. Choline, folate and homocysteine metabolism are closely inter-related. The pathways for the metabolism of these three nutrients intersect at the formation of methionine from homocysteine. PtdEtn = phosphatidylethanolamine, AdoHcy = S-adenosylhomocysteine, SAM = S-adenosylmethionine, B12 = vitamin B12, PEMT = phosphatidylethanolamine methyltransferase, MTHFR = methyltetrahydrofolate reductase.

 




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